Plethysmography measurements of respiratory function in conscious unrestrained mice
نویسندگان
چکیده
منابع مشابه
Measuring respiratory function in mice using unrestrained whole-body plethysmography.
Respiratory dysfunction is one of the leading causes of morbidity and mortality in the world and the rates of mortality continue to rise. Quantitative assessment of lung function in rodent models is an important tool in the development of future therapies. Commonly used techniques for assessing respiratory function including invasive plethysmography and forced oscillation. While these technique...
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Presently, unrestrained plethysmography is widely used to assess bronchial responsiveness in mice. An empirical quantity known as enhanced pause is derived from the plethysmographic box pressure [P(b)(t), where t is time] and assumed to be an index of bronchoconstriction. We show that P(b)(t) is determined largely by gas conditioning when normal mice breathe spontaneously inside a closed chambe...
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Type 2 diabetes is characterized by a defect in insulin action. The hyperinsulinemic-euglycemic clamp, or insulin clamp, is widely considered the "gold standard" method for assessing insulin action in vivo. During an insulin clamp, hyperinsulinemia is achieved by a constant insulin infusion. Euglycemia is maintained via a concomitant glucose infusion at a variable rate. This variable glucose in...
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متن کاملRespiratory monitoring by inductive plethysmography in unrestrained subjects using position sensor-adjusted calibration.
BACKGROUND Portable respiratory inductive plethysmography (RIP) is promising for noninvasive monitoring of breathing patterns in unrestrained subjects. However, its use has been hampered by requiring recalibration after changes in body position. OBJECTIVES To facilitate RIP application in unrestrained subjects, we developed a technique for adjustment of RIP calibration using position sensor f...
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ژورنال
عنوان ژورنال: The Journal of Physiological Sciences
سال: 2015
ISSN: 1880-6546,1880-6562
DOI: 10.1007/s12576-015-0408-1